Scrub Typhus: A review

garima pal

Abstract


Scrub typhus may be a zoonosis caused by Orientia tsutsugamushi, that is transmitted by chiggers. The target cells of this bacterium square measure poorly outlined in humans. It was undertaken in six elite study areas India Jammu, Akhnoor, Rajouri Poonch, Udhampur- Nagrota, Dehradun and Pune. rickettsiosis is associate degree acute infectious unwellness, distributed throughout the Asia Pacific rim. In India, it's been according from northern, eastern, and southern India. However, cases of rickettsiosis haven't been well‑documented from Vidarbha, associate degree jap region of geographic area state in central Bharat. The designation in each cases was supported presence of scab, a positive Weil‑Felix check, and a positive fast assay (immunochromatographic assay). once associate degree time period of 6-21 days, onset is characterised by fever, headache, myalgia, cough, and gi symptoms. The suggested treatment programme for rickettsiosis is antibiotic. various regimens embody antibacterial drug, antibiotic drug, azithromycin, Cipro, rifampicin, and roxithromyci. In July 2006, associate degree Australian holidaymaker getting back from metropolis, within the United Arab Emirates (UAE), developed acute rickettsiosis. The distinguishing associate degree scab in rickettsiosis is helpful for initiation of prompt and applicable antibiotic medical care.


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Kelly DJ, Fuerst PA, Ching WM, Richards AL. Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi.

Sinha P, Gupta S, Dawra R, Rijhawan P. Recent outbreak of scrub typhus in North Western part of India. Indian journal of medical microbiology. 2014

Kelly DJ, Fuerst PA, Ching WM, Richards AL. Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi. Clinical Infectious Diseases. 2009

Tattersall RN. Tsutsugamushi Fever on the India-Burma Border. Lancet. 1945:392-4.

Varghese GM, Abraham OC, Mathai D, Thomas K, Aaron R, Kavitha ML, Mathai E. Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. Journal of Infection. 2006 Jan 1;52(1):56-60.

Sinha P, Gupta S, Dawra R, Rijhawan P. Recent outbreak of scrub typhus in North Western part of India. Indian journal of medical microbiology. 2014 Jul 1;32(3):247.

Dass R, Deka NM, Duwarah SG, Barman H, Hoque R, Mili D, Barthakur D. Characteristics of pediatric scrub typhus during an outbreak in the North Eastern region of India: peculiarities in clinical presentation, laboratory findings and complications. The Indian Journal of Pediatrics. 2011 Nov 1;78(11):1365-70.

Chrispal A, Boorugu H, Gopinath KG, Prakash JA, Chandy S, Abraham OC, Abraham AM, Thomas K. Scrub typhus: an unrecognized threat in South India–clinical profile and predictors of mortality. Tropical doctor. 2010 Jul;40(3):129-33.

Khan SA, Dutta P, Khan AM, Topno R, Borah J, Chowdhury P, Mahanta J. Re-emergence of scrub typhus in northeast India. International Journal of Infectious Diseases. 2012 Dec 1;16(12):e889-90.

Kelly DJ, Fuerst PA, Ching WM, Richards AL. Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi.

Kalra SL. Natural History of Typhus Fevers in India. Indian Journal of Medical Sciences. 1952;6(9):569-75.

Varghese GM, Abraham OC, Mathai D, Thomas K, Aaron R, Kavitha ML, Mathai E. Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. Journal of Infection. 2006 Jan 1;52(1):56-60.

Suputtamongkol Y, Suttinont C, Niwatayakul K, Hoontrakul S, Limpaiboon R, Chierakul W, Losuwanaluk K, Saisongkork W. Epidemiology and clinical aspects of rickettsioses in Thailand. Annals of the New York Academy of Sciences. 2009 May 1;1166(1):172-9

Trishnananda M, Vasuvat C, Harinasuta C. Investigation of scrub typhus in Thailand. Tropical Medicine and Hygiene News. 1964;67(9):215-19.

Suputtamongkol Y, Suttinont C, Niwatayakul K, Hoontrakul S, Limpaiboon R, Chierakul W, Losuwanaluk K, Saisongkork W. Epidemiology and clinical aspects of rickettsioses in Thailand. Annals of the New York Academy of Sciences. 2009 May 1;1166(1):172-9.

Currie B, O'Connor L, Dwyer B. A new focus of scrub typhus in tropical Australia. The American journal of tropical medicine and hygiene. 1993 Oct 1;49(4):425-9.

Graves S, Unsworth N, Stenos J. Rickettsioses in Australia. Annals of the New York Academy of Sciences. 2006 Oct;1078(1):74-9.

Tay ST, Nazma S, Rohani MY. Diagnosis of scrub typhus in Malaysian aborigines using nested polymerase chain reaction. Southeast Asian journal of tropical medicine and public health. 1996 Sep;27:580-3.

Cadigan Jr FC, Andre RG, Bolton M, Gan E, Walker JS. The effect of habitat on the prevalence of human scrub typhus in Malaysia. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1972 Jan 1;66(4):582-7.

Robinson DM, Gan E, Donaldson JR. The prevalence of scrub typhus antibodies in residents of West Malaysia. Tropical and Geographical Medicine. 1976 Dec;28(4):303-8.

Spicer PE, Taufa T, Benjamin AL. Scrub typhus (Orientia tsutsugamushi), spotted fever (Rickettsia australis) and dengue fever as possible causes of mysterious deaths in the Strickland Gorge area of Southern Highlands and West Sepik Provinces of Papua New Guinea. Papua New Guinea Medical Journal. 2007 Sep;50(3/4):172.

Miles JA, Austin FJ, Jennings LC. Scrub typhus in the eastern Solomon Islands and northern Vanuatu (New Hebrides). The American journal of tropical medicine and hygiene. 1981 Jul 1;30(4):849-54.

IRONS EN, ARMSTRONG HE. Scrub typhus in dutch new guinea. Annals of internal medicine. 1947 Feb 1;26(2):201-20.

Pham XD, Otsuka Y, Suzuki H, Takaoka H. Detection of Orientia tsutsugamushi (Rickettsiales: Rickettsiaceae) in unengorged chiggers (Acari: Trombiculidae) from Oita Prefecture, Japan, by nested polymerase chain reaction. Journal of medical entomology. 2001 Mar 1;38(2):308-11

Rajapakse S, Rodrigo C, Fernando D. Scrub typhus: pathophysiology, clinical manifestations and prognosis. Asian Pacific journal of tropical medicine. 2012 Apr 1;5(4):261-4.

Brown GW, Robinson DM, Huxsoll DL, Ng TS, Lim KJ, Sannasey G. Scrub typhus: a common cause of illness in indigenous populations. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1976 Jan 1;70(5-6):444-8.

Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, Phiasakha K, Soukkhaseum S, Frichithavong K, Chu V, Keolouangkhot V. Rickettsial infections and fever, Vientiane, Laos. Emerging infectious diseases. 2006 Feb;12(2):256.

Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, Suwancharoen D, Panlar P, Saisongkorh W, Rolain JM, Raoult D. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Annals of Tropical Medicine & Parasitology. 2006 Jun 1;100(4):363-70.

Brown GW, Robinson DM, Huxsoll DL, Ng TS, Lim KJ, Sannasey G. Scrub typhus: a common cause of illness in indigenous populations. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1976 Jan 1;70(5-6):444-8.

Yamamoto S, Ganmyo H, Iwakiri A, Suzuki S. Annual incidence of tsutsugamushi disease in Miyazaki prefecture, Japan in 2001-2005. Japanese journal of infectious diseases. 2006 Dec 1;59(6):404

Bang H, Lee M, Lee W. Comparative research on epidemiological aspects of tsutsugamushi disease (scrub typhus) between Korea and Japan. Japanese journal of infectious diseases. 2008 Mar 1;61(2):148.

Jain P, Prakash S, Tripathi PK, Chauhan A, Gupta S, Sharma U, Jaiswal AK, Sharma D, Jain A. Emergence of Orientia tsutsugamushi as an important cause of Acute Encephalitis Syndrome in India. PLoS neglected tropical diseases. 2018 Mar 28;12(3):e0006346.

Yamamoto SE, Minamishima YO. Serodiagnosis of tsutsugamushi fever (scrub typhus) by the indirect immunoperoxidase technique. Journal of Clinical Microbiology. 1982 Jun 1;15(6):1128-32.

Kelly DJ, Wong PW, Gan E, Lewis Jr GE. Comparative evaluation of the indirect immunoperoxidase test for the serodiagnosis of rickettsial disease. The American journal of tropical medicine and hygiene. 1988 Mar 1;38(2):400-6.

Reller ME, Dumler JS. Scrub typhus (Orientia tsutsugamushi). Kliegman: Nelson Textbook of Pediatrics. Nineteenth ed: Saunders, An Imprint of Elsevier. 2011:1045-6

Phimda K, Hoontrakul S, Suttinont C, Chareonwat S, Losuwanaluk K, Chueasuwanchai S, Chierakul W, Suwancharoen D, Silpasakorn S, Saisongkorh W, Peacock SJ. Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus. Antimicrobial agents and chemotherapy. 2007 Sep 1;51(9):3259-63.

Watt G, Chouriyagune C, Ruangweerayud R, Watcharapichat P, Phulsuksombati D, Jongsakul K, Teja-Isavadharm P, Bhodhidatta D, Corcoran KD, Dasch GA, Strickman D. Scrub typhus infections poorly responsive to antibiotics in northern Thailand. The Lancet. 1996 Jul 13;348(9020):86-9

Watt G, Parola P. Scrub typhus and tropical rickettsioses. Current opinion in infectious diseases. 2003 Oct 1;16(5):429-36.

Kollars Jr TM, Bodhidatta D, Phulsuksombati D, Tippayachai B, Coleman RE. Variation in the 56-kD type-specific antigen gene of Orientia tsutsugamushi isolated from patients in Thailand. The American journal of tropical medicine and hygiene. 2003 Mar 1;68(3):299-300.

Watt G, Kantipong P, Jongsakul K, Watcharapichat P, Phulsuksombati D, Strickman D. Doxycycline and rifampicin for mild scrub-typhus infections in northern Thailand: a randomised trial. The Lancet. 2000 Sep 23;356(9235):1057-61.

Watt G, Chouriyagune C, Ruangweerayud R, Watcharapichat P, Phulsuksombati D, Jongsakul K, Teja-Isavadharm P, Bhodhidatta D, Corcoran KD, Dasch GA, Strickman D. Scrub typhus infections poorly responsive to antibiotics in northern Thailand. The Lancet. 1996 Jul 13;348(9020):86-9.

Arguin PM, Kozarsky PE, Reed C (2008). "Chapter 4: Rickettsial Infections"C. DC Health Information for International Travel, 2008 .

Langade DG. Treatment Update for Scrub Typhus. Indian Medical Gazette. 2011 Nov.

Kaore SN, Sharma P, Yadav VK, Sharma R, Kaore NM, Langade DG. Treatment Update for Scrub Typhus.

Kelly DJ, Fuerst PA, Ching WM, Richards AL. Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi. Clinical Infectious Diseases. 2009 Mar 15;48(Supplement_3):S203-30.


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