The soluble epoxide hydrolase sEH inhibitory activity of coumarins from the leaves of Murraya paniculata

Cuong Manh Nguyen, Duc Viet Ho, Tai Huu Bui

Abstract


In the search for novel chemical structures leading to potential anti-hypertensive and anti-inflammatory agents based on the inhibitory activity of soluble epoxide hydrolase (sEH), four coumarins isolated from the chloroform fraction deprived from the methanol extract of the Murraya paniculata leaves was assessed for its effects on sEH inhibitory effects. The two coumarins (-)-murracarpin (2) and murrangatin (3) showed sEH inhibitory activity in range of 0.65 - 1.56 μM. The coumarins omphalocarpin (4) and kimcuongin (1) showed potent sEH inhibitory activity with IC50 values of 21.9 μM and 35.6 μM, respectively. The coumarin omphalocarpin (4) may thus represent a novel class of cardiovascular agent for enzyme soluble epoxide hydroxylase inhibition from natural source.

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