Study of Urine Hydroxyproline Creatinine Ratio as a Marker of Bone Metastases of Breast Cancer Patients In Comparison With Bone Scintigraphy

B.K.D Sarvari, D Sankar Mahadev, S.A Masthan, S Rupa


Skeletal metastases are common occurrences in patients with breast cancer but are difficult to diagnose non-radiologically, and treatment is difficult to follow clinically. This study was designed to evaluate the utility of the bone resorption marker, hydroxyproline creatinine ratio(OHPr: Cr ratio) in urine and the bone formation marker such as serum total alkaline phosphatase (ALP), in comparison with whole body skeletal scintigraphy with Technetium99ᵐ MDP for the diagnosis of bone metastasis(BM) in breast cancer(BC) patients. Experimental design: Four groups of samples were analysed. 1st group consists 52 normal female (cancer free women), 2nd group consists 38 BC patients without BM,3rd group 27 BC patients with limited BM and 4th group comprising of 35 BC patients with extensive BM conformed by whole body skeletal scintigraphy with Technetium99ᵐ MDP. One way ANOVA was used to comparefasting urineOHPr: Cr ratio and ALP among thesegroups. BothurineOHPr: Crratioand ALP are not markedly elevated in limited bone metastasis but are strongly elevated in extensive bone metastasis (P<0.0001).

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