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Quantitative Structure Activity Relationship (QSAR) Studies of Some Novel Anti-diabetic Drugs

Gaurav Bajpai, Suman Malik

Abstract


Diabetes is a metabolic disorder characterized by resistance to the action of insulin, insufficient insulin secretion, or both. The clinical manifestation of these disorders is hyperglycemia.The primary goals of DM management are to reduce the risk for microvascular and macrovascular disease complications, to ameliorate symptoms, to reduce mortality, and to improve quality of life.PPARs are members of the nuclear receptor family that play a central role in the regulation of storage and catabolism of dietary fats. The three subtypes of PPAR (designated a, g and b/d) bind to fatty acids (FFAs) and FFA metabolites and regulate the expression of genes involved in the transport, metabolism and buffering of these ligands within cells.Thiazolidinedionesbased antidiabetic drugs such as pioglitazone, rosiglitazone and triglitazone have associated side effects such as weight gain, edema and anaemia. Thus QSAR approach is used in this research paper to develop a potent thiazolidinediones based antidiabetic compound free from side effects.

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