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Antihyperlipidemic effect of Bougainvillea glabra leaves in high fat diet induced hyperlipidemic rats

Brajesh Garg, N.M. Srivastava, Savita Srivastava

Abstract


Objective: The aim was to evaluate the antihyperlipidemic effect of Bougainvillea glabra leaves in high fat diet induced hyperlipidemic rats. Materials and Methods: Ethanolic extract (EE), aqueous extract (AE), chloroform fraction of ethanolic extract (CF) and ethylacetate fraction of ethanolic extract (EAF) of Bougainvillea glabra leaves administered at different doses to the high fat diet (HFD) induced hyperlipidemic rats. The serum levels of lipid profile were examined by standard procedures. Results: Bougainvillea glabra has revealed a significant (P<0.05) decrease in the levels of serum total cholesterol, triglyceride, LDL and significant increase in the level of serum HDL. Conclusions: The results of this study strongly indicate that the ethylacetate fraction of ethanolic extract has a potent antihyperlipidaemic action against HFD-induced hyperlipidemic rats.

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